As a freshman in 2018, appeared in 9 games and recorded eight tackles, 6 PDs and 2 INTs. As a sophomore in 2019 at Pearl River Community College, appeared in 9 games and registered 19 tackles, 8 PDs and 1 INT, earning a spot on the All-Mississippi Association of Community & Junior Colleges Second-Team. As a junior in 2020, appeared in all 11 games and added 28 tackles, 1 PD and 1 FF. Was also named Sun Belt Defensive Player of the Year and Second-Team All-American by Pro Football Focus.

In 2021, appeared in 12 games and tallied 21 tackles, 10 PDs and 4 INTs, earning First-Team All-Sun Belt honors. In 2022, appeared in 13 games and notched 37 tackles, 5 PDs and 1 INT, earning Third-Team All-Sun Belt honors. He appeared in 36 games in three years (2020-22) at South Alabama and registered 86 tackles, 16 PDs, 5 INTs and 1 FF after transferring from Pearl River (Poplarville, MS) Community College where he appeared in 18 games in two seasons (2018-19) and recorded 27 tackles, 14 PDs and 3 INTs. (6-0, 190) was the first of two fifth-round draft picks (155th overall) selected by the 49ers in this year's NFL Draft. Tallied 40 tackles, 5 INTs and 3 PDs as a freshman in 2018. Appeared in 9 games and registered 35 tackles, 5 PDs, 3 INTs and 1 FR as a sophomore in 2019 where he earned the Northeast Football Conference's Defensive Player of the Year Award, First-Team All-NEFC and NJCAA First-Team All-American honors. Helped guide Lackawanna to a 21-1 record and a trip to the NJCAA Championship Game during his 2 years with the team. Appeared in 9 games as a junior in 2020 and posted 6 tackles and 1 PD. In 2021, started all 13 games at S and tallied 73 tackles, 11 PDs, 6 INTs, 2 FRs and 1 FF, earning Third-Team All-Big Ten honors. In 2022, started all 13 games at S and notched 74 tackles, 7.0 TFLs, 4.5 sacks, 2 FFs and 1 FR, earning Third-Team All-Big Ten honors for the second-consecutive season.

He appeared in 35 games (26 starts) in three years (2020-22) at Penn State and registered 153 tackles, 19 PDs, 10 INTs, 9.0 TFLs, 4.5 sacks, 3 FFs and 3 FRs after transferring from Lackawanna Community College (Scranton, PA) where he spent two seasons (2018-19). Brown (5-11, 202) was the first of three third-round draft picks (87th overall) selected by the 49ers in this year's NFL Draft.

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